Version 5.4
Homo sapiens Gene: TTYH3
Summary
InnateDB Gene IDBG-7076.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTYH3
Gene Name tweety homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136295
Encoded Proteins
IDBP-7078
tweety homolog 3 (Drosophila)
IDBP-228402
tweety homolog 3 (Drosophila)
IDBP-292547
tweety homolog 3 (Drosophila)
IDBP-292549
tweety homolog 3 (Drosophila)
IDBP-361856
tweety homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:2631951-2664802
Strand Forward strand
Band p22.3
Transcripts
ENST00000258796 ENSP00000258796
ENST00000400376 ENSP00000383227
ENST00000407643 ENSP00000385316
ENST00000403167 ENSP00000385015
ENST00000429448 ENSP00000413757
ENST00000477439
ENST00000498454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036565
View Gene Order
ENSBTAG00000005934
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440899 Hs.622255
RefSeq NM_025250
HUGO
OMIM
CCDS CCDS34588
HPRD 12333
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca