Version 5.4
Homo sapiens Protein: TTYH3
Summary
InnateDB Protein IDBP-7078.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTYH3
Protein Name tweety homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258796
InnateDB Gene IDBG-7076 (TTYH3)
Protein Structure
UniProt Annotation
Function Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. {ECO:0000269PubMed:15010458}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15010458}; Multi-pass membrane protein {ECO:0000269PubMed:15010458}.
Disease Associations
Tissue Specificity Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. {ECO:0000269PubMed:15010458}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006990 Tweety
PFAM PF04906
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0H2
PhosphoSite PhosphoSite-Q9C0H2
TrEMBL A0A024R816
UniProt Splice Variant
Entrez Gene 80727
UniGene Hs.622255
RefSeq NP_079526
HUGO HGNC:22222
OMIM 608919
CCDS CCDS34588
HPRD 12333
IMGT
EMBL AB051478 AB162931 AC006028 AC073462 AK074158 AK124608 BC131824 BC152447 BE263005 CH236953 CH471144
GenPept AAI31825 AAI52448 BAB21782 BAB84984 BAC85898 BAD20190 EAL23958 EAW87266 EAW87267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca