InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Npnt

Summary

InnateDB Gene

IDBG-194680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npnt

Gene Name

nephronectin

Synonyms

1110009H02Rik; AA682063; AI314031; Nctn; POEM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040998

Encoded Proteins

IDBP-194682

nephronectin

IDBP-194684

nephronectin

IDBP-194686

nephronectin

IDBP-400411

nephronectin

IDBP-400409

nephronectin

IDBP-400408

nephronectin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168743:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:132881745-132950291

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042729	ENSMUSP00000040071
ENSMUST00000042744	ENSMUSP00000040684
ENSMUST00000093971	ENSMUSP00000091505
ENSMUST00000117811	ENSMUSP00000113752
ENSMUST00000117164	ENSMUSP00000113419
ENSMUST00000117456	ENSMUSP00000112816
ENSMUST00000132732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0007160	cell-matrix adhesion
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033631	cell-cell adhesion mediated by integrin
GO:0045184	establishment of protein localization
GO:0045669	positive regulation of osteoblast differentiation
GO:0045987	positive regulation of smooth muscle contraction
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071356	cellular response to tumor necrosis factor
GO:0097195	pilomotor reflex
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0016020	membrane
GO:0030485	smooth muscle contractile fiber
GO:0031012	extracellular matrix
GO:0034678	alpha8-beta1 integrin complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168743

View Gene Order

ENSBTAG00000006686

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04512

ECM-receptor interaction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

integrin1_pathway

Beta1 integrin cell surface interactions

Cross-References

SwissProt

Q91V88

TrEMBL

D3YTX1

UniProt Splice Variant

Entrez Gene

114249

UniGene

Mm.279310 Mm.440226

RefSeq

NM_033525 NM_001029836 NM_001287101 NM_001287102 NM_001287103 XM_006500915

OMIM

CCDS

CCDS17846 CCDS17845 CCDS71321 CCDS71322 CCDS71323

HPRD

IMGT

MGI ID

MGI:2148811

MGI Symbol

Npnt

EMBL

AB059656 AC139942 AF397007 AF397008 AK050484 AY035898 AY035899 BC046642 BC068308

GenPept

AAH46642 AAH68308 AAK84391 AAK84392 AAK96010 AAK96011 BAB69692 BAC34283

RNA Seq Atlas

114249