InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npnt

Summary

InnateDB Protein

IDBP-194686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npnt

Protein Name

nephronectin

Synonyms

1110009H02Rik; AA682063; AI314031; Nctn; POEM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091505

InnateDB Gene

IDBG-194680 (Npnt)

Protein Structure

UniProt Annotation

Function

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins. {ECO:0000269PubMed:11470831, ECO:0000269PubMed:11546798, ECO:0000269PubMed:17537792}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:11470831, ECO:0000269PubMed:11546798}. Note=Trapped on the cell surface or in the extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in kidney (at protein level). {ECO:0000269PubMed:11470831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0007160	cell-matrix adhesion
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033631	cell-cell adhesion mediated by integrin
GO:0045184	establishment of protein localization
GO:0045669	positive regulation of osteoblast differentiation
GO:0045987	positive regulation of smooth muscle contraction
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071356	cellular response to tumor necrosis factor
GO:0097195	pilomotor reflex
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0016020	membrane
GO:0030485	smooth muscle contractile fiber
GO:0031012	extracellular matrix
GO:0034678	alpha8-beta1 integrin complex

Protein Structure and Domains

PDB ID

MGI:2148811

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF07645

PRINTS

PR00020

PIRSF

SMART

SM00181
SM00137
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt