Version 5.4
Homo sapiens Gene: GIT1
Summary
InnateDB Gene IDBG-38394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIT1
Gene Name G protein-coupled receptor kinase interacting ArfGAP 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108262
Encoded Proteins
IDBP-38396
G protein-coupled receptor kinase interacting ArfGAP 1
IDBP-38398
G protein-coupled receptor kinase interacting ArfGAP 1
IDBP-240701
G protein-coupled receptor kinase interacting ArfGAP 1
IDBP-760651
IDBP-758647
IDBP-759001
IDBP-764403
IDBP-762534
IDBP-762621
IDBP-757882
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:29573469-29594054
Strand Reverse strand
Band q11.2
Transcripts
ENST00000225394 ENSP00000225394
ENST00000335356 ENSP00000334125
ENST00000394869 ENSP00000378338
ENST00000473217
ENST00000491377
ENST00000586574
ENST00000581348 ENSP00000462775
ENST00000579937 ENSP00000464388
ENST00000581925
ENST00000579536
ENST00000578670 ENSP00000463746
ENST00000583413 ENSP00000466824
ENST00000578266 ENSP00000463435
ENST00000585148 ENSP00000463543
ENST00000577466 ENSP00000464933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0016235 aggresome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011877
View Gene Order
ENSBTAG00000012040
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228226
Ephrin signaling pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
cdc42_reg_pathway
Regulation of CDC42 activity
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt Q9Y2X7
TrEMBL K7EIX6
UniProt Splice Variant
Entrez Gene 28964
UniGene Hs.514051
RefSeq NM_001085454 NM_014030
HUGO HGNC:4272
OMIM 608434
CCDS CCDS11250 CCDS42290
HPRD 06577
IMGT
EMBL AC104564 AF124490 AK294785 AK299932 BC006227 BC048196
GenPept AAD28046 AAH06227 AAH48196 BAG57910 BAG61765
RNA Seq Atlas 28964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca