Version 5.4
Mus musculus Gene: Birc6
Summary
InnateDB Gene IDBG-197962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc6
Gene Name baculoviral IAP repeat-containing 6
Synonyms A430032G04Rik; A430040A19Rik; AA501170; Bruce; D630005A10Rik; mKIAA1289
Species Mus musculus
Ensembl Gene ENSMUSG00000024073
Encoded Proteins
IDBP-714166
IDBP-715291
IDBP-790492
baculoviral IAP repeat-containing 6
IDBP-790493
baculoviral IAP repeat-containing 6
IDBP-790494
baculoviral IAP repeat-containing 6
IDBP-790495
baculoviral IAP repeat-containing 6
IDBP-790496
baculoviral IAP repeat-containing 6
IDBP-790497
baculoviral IAP repeat-containing 6
IDBP-790498
baculoviral IAP repeat-containing 6
IDBP-790499
baculoviral IAP repeat-containing 6
IDBP-790500
baculoviral IAP repeat-containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115760:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74528295-74703356
Strand Forward strand
Band E2
Transcripts
ENSMUST00000177957 ENSMUSP00000137114
ENSMUST00000180037 ENSMUSP00000136329
ENSMUST00000182944 ENSMUSP00000138732
ENSMUST00000182597 ENSMUSP00000138333
ENSMUST00000182133 ENSMUSP00000138693
ENSMUST00000182382
ENSMUST00000183224 ENSMUSP00000138270
ENSMUST00000182631
ENSMUST00000183189
ENSMUST00000182257
ENSMUST00000182362
ENSMUST00000182108
ENSMUST00000182323 ENSMUSP00000138672
ENSMUST00000182845 ENSMUSP00000138717
ENSMUST00000182164
ENSMUST00000182278 ENSMUSP00000138343
ENSMUST00000182221
ENSMUST00000182206
ENSMUST00000182817 ENSMUSP00000138349
ENSMUST00000183010
ENSMUST00000183249 ENSMUSP00000138521
ENSMUST00000182147
ENSMUST00000182804
ENSMUST00000182157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0001890 placenta development
GO:0006464 cellular protein modification process
GO:0006915 apoptotic process
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0010951 negative regulation of endopeptidase activity
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0032465 regulation of cytokinesis
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0030496 midbody
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115760
View Gene Order
ENSBTAG00000027932
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_007566 XM_006523522 XM_006523523 XM_006523524 XM_006523525 XM_006523526
OMIM
CCDS CCDS37693
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca