Version 5.4
Homo sapiens Gene: BIRC6
Summary
InnateDB Gene IDBG-43545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIRC6
Gene Name baculoviral IAP repeat containing 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115760
Encoded Proteins
IDBP-371931
baculoviral IAP repeat containing 6
IDBP-371940
baculoviral IAP repeat containing 6
IDBP-371944
baculoviral IAP repeat containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32357028-32618899
Strand Forward strand
Band p22.3
Transcripts
ENST00000421745 ENSP00000393596
ENST00000444173 ENSP00000413090
ENST00000431454 ENSP00000393590
ENST00000466527
ENST00000483194
ENST00000462504
ENST00000497023
ENST00000496555
ENST00000461788
ENST00000471232
ENST00000470250
ENST00000465130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0001890 placenta development
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007067 mitotic nuclear division
GO:0008284 positive regulation of cell proliferation
GO:0010951 negative regulation of endopeptidase activity
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0032465 regulation of cytokinesis
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024073
View Gene Order
ENSBTAG00000027932
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H7C3P0
UniProt Splice Variant
Entrez Gene 57448
UniGene Hs.150107 Hs.707206
RefSeq NM_016252 XM_005264453
HUGO HGNC:13516
OMIM 605638
CCDS CCDS33175
HPRD 05731
IMGT
EMBL AC079837 AL133243 AL133245 AL133246
GenPept
RNA Seq Atlas 57448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca