Version 5.4
Mus musculus Gene: Ptprn
Summary
InnateDB Gene IDBG-170581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprn
Gene Name protein tyrosine phosphatase, receptor type, N
Synonyms IA-2; mIA-A; mKIAA4064
Species Mus musculus
Ensembl Gene ENSMUSG00000026204
Encoded Proteins
IDBP-170583
protein tyrosine phosphatase, receptor type, N
IDBP-788297
protein tyrosine phosphatase, receptor type, N
IDBP-788302
protein tyrosine phosphatase, receptor type, N
IDBP-788303
protein tyrosine phosphatase, receptor type, N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054356:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:75247027-75264502
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000027404 ENSMUSP00000027404
ENSMUST00000187216
ENSMUST00000186178 ENSMUSP00000139925
ENSMUST00000189769 ENSMUSP00000140168
ENSMUST00000185849 ENSMUSP00000140062
ENSMUST00000188401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0030507 spectrin binding
GO:0051020 GTPase binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006470 protein dephosphorylation
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0009749 response to glucose
GO:0016311 dephosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0032868 response to insulin
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043627 response to estrogen
GO:0051591 response to cAMP
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000054356
View Gene Order
ENSBTAG00000013798
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04940
Type I diabetes mellitus pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 19275
UniGene
RefSeq NM_008985 XM_006496444 XM_006496445
OMIM
CCDS CCDS35625
HPRD
IMGT
MGI ID MGI:102765
MGI Symbol Ptprn
EMBL
GenPept
RNA Seq Atlas 19275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca