Version 5.4
| Homo sapiens Gene: PTPRN | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-81527.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PTPRN | ||||||||||||||||||
| Gene Name | protein tyrosine phosphatase, receptor type, N | ||||||||||||||||||
| Synonyms | IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000054356 | ||||||||||||||||||
| Encoded Proteins |
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 2:219289623-219309648 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q35 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Type I diabetes mellitus pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.715412 Hs.89655 | ||||||||||||||||||
| RefSeq | NM_001199763 NM_001199764 NM_002846 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS2440 CCDS56167 CCDS56168 | ||||||||||||||||||
| HPRD | 03466 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||