InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mff

Summary

InnateDB Protein

IDBP-534386.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mff

Protein Name

mitochondrial fission factor

Synonyms

5230400G24Rik; AI314724;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124200

InnateDB Gene

IDBG-173985 (Mff)

Protein Structure

UniProt Annotation

Function

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. {ECO:0000269PubMed:23283981}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000266	mitochondrial fission
GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0008053	mitochondrial fusion
GO:0016559	peroxisome fission
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0051260	protein homooligomerization
GO:0070584	mitochondrion morphogenesis
GO:0090141	positive regulation of mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090314	positive regulation of protein targeting to membrane
GO:1900063	regulation of peroxisome organization

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0032592	integral component of mitochondrial membrane