Version 5.4
Mus musculus Gene: Mff
Summary
InnateDB Gene IDBG-173985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mff
Gene Name mitochondrial fission factor
Synonyms 5230400G24Rik; AI314724
Species Mus musculus
Ensembl Gene ENSMUSG00000026150
Encoded Proteins
IDBP-173987
mitochondrial fission factor
IDBP-173989
mitochondrial fission factor
IDBP-532536
mitochondrial fission factor
IDBP-535777
mitochondrial fission factor
IDBP-537260
mitochondrial fission factor
IDBP-534386
mitochondrial fission factor
IDBP-533876
mitochondrial fission factor
IDBP-541462
mitochondrial fission factor
IDBP-540573
mitochondrial fission factor
IDBP-540237
mitochondrial fission factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24733894
[Homo sapiens] Hepatitis C infection stimulates the expression of DNM1L and MFF and promotes DNM1L recruitment to mitochondria by stimulating the phosphorylation of DNM1L, leading to mitochondrial fission.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168958:
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:82724890-82752394
Strand Forward strand
Band C5
Transcripts
ENSMUST00000078332 ENSMUSP00000077446
ENSMUST00000073025 ENSMUSP00000072784
ENSMUST00000161572
ENSMUST00000161648 ENSMUSP00000124164
ENSMUST00000162056
ENSMUST00000160786 ENSMUSP00000125230
ENSMUST00000162003 ENSMUSP00000124334
ENSMUST00000160972 ENSMUSP00000124200
ENSMUST00000160750 ENSMUSP00000125223
ENSMUST00000159279 ENSMUSP00000123713
ENSMUST00000160044 ENSMUSP00000125005
ENSMUST00000160744 ENSMUSP00000125629
ENSMUST00000160632
ENSMUST00000162794
ENSMUST00000162573
ENSMUST00000188333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0051260 protein homooligomerization
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090314 positive regulation of protein targeting to membrane
GO:1900063 regulation of peroxisome organization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0032592 integral component of mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168958
View Gene Order
ENSBTAG00000021319
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.396863 Mm.479553 Mm.489133
RefSeq NM_029409 XM_006496568 XM_006496569 XM_006496570 XM_006496571 XM_006496572 XM_006496573
OMIM
CCDS CCDS15098
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca