InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANO10

Summary

InnateDB Protein

IDBP-28405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANO10

Protein Name

anoctamin 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292246

InnateDB Gene

IDBG-28403 (ANO10)

Protein Structure

UniProt Annotation

Function

Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22075693, ECO:0000269PubMed:22946059}; Multi- pass membrane protein {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22075693, ECO:0000269PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.

Disease Associations

Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO:0000269PubMed:21092923}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain. {ECO:0000269PubMed:21092923}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005227	calcium activated cation channel activity
GO:0005229	intracellular calcium activated chloride channel activity

Biological Process

GO:0006812	cation transport
GO:0006821	chloride transport
GO:0008219	cell death
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport