InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pan3

Summary

InnateDB Protein

IDBP-209070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pan3

Protein Name

PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae)

Synonyms

2700050F09Rik; A430027N15Rik; AU014670;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031651

InnateDB Gene

IDBG-209068 (Pan3)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255HAMAP-Rule:MF_03181}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03181, ECO:0000269PubMed:18625844}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0006605	protein targeting
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005813	centrosome
GO:0031251	PAN complex

Protein Structure and Domains

PDB ID

MGI:1919837

InterPro

IPR000571 Zinc finger, CCCH-type
IPR000719 Protein kinase domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00642
PF00069

PRINTS

PIRSF

SMART

SM00356
SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q640Q5