Version 5.4
Mus musculus Protein: Ttyh3
Summary
InnateDB Protein IDBP-206983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttyh3
Protein Name tweety homolog 3 (Drosophila)
Synonyms 2900029G13Rik; AI414930;
Species Mus musculus
Ensembl Protein ENSMUSP00000037447
InnateDB Gene IDBG-206981 (Ttyh3)
Protein Structure
UniProt Annotation
Function Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. Also expressed in fat, the pancreas, thymus, and uterus. {ECO:0000269PubMed:15010458}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1925589
InterPro IPR006990 Tweety
PFAM PF04906
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P5F7
PhosphoSite PhosphoSite-Q6P5F7
TrEMBL
UniProt Splice Variant
Entrez Gene 78339
UniGene Mm.28947
RefSeq NP_780483
MGI ID
MGI Symbol Ttyh3
OMIM
CCDS CCDS19822
HPRD
IMGT
EMBL AK052340 AK173233 BC059083 BC062917
GenPept AAH59083 AAH62917 BAC34944 BAD32511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca