InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde8a

Summary

InnateDB Protein

IDBP-195969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde8a

Protein Name

phosphodiesterase 8A

Synonyms

AI551852; Pde8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026672

InnateDB Gene

IDBG-195967 (Pde8a)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest levels in testis > eye > liver > skeletal muscle > heart > 7-day embryo > kidney > ovary > brain. In the testis, expressed specifically in the seminiferous epithelium in a spatial and temporal manner.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1277116

InterPro

IPR000014 PAS domain
IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF13188
PF13426
PF00072
PF00233
PF08448
PF00989

PRINTS

PR00387

PIRSF

SMART

SM00091
SM00448
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt