InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde8a

Summary

InnateDB Gene

IDBG-195967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde8a

Gene Name

phosphodiesterase 8A

Synonyms

AI551852; Pde8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025584

Encoded Proteins

IDBP-195969

phosphodiesterase 8A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073417:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:81213596-81334533

Strand

Forward strand

Band

Transcripts

ENSMUST00000026672	ENSMUSP00000026672
ENSMUST00000128154
ENSMUST00000130494

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0070062

extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000073417

View Gene Order

ENSBTAG00000015909

Not yet available

Pathways

NETPATH

REACTOME

REACT_242871

G alpha (s) signalling events pathway

REACT_223625

GPCR downstream signaling pathway

REACT_254215

Signaling by GPCR pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.371577 Mm.451739

RefSeq

NM_008803

OMIM

CCDS

CCDS40005

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas