InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sergef

Summary

InnateDB Protein

IDBP-186123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sergef

Protein Name

secretion regulating guanine nucleotide exchange factor

Synonyms

DelGEF; Gef; Gnef; Gnefr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033127

InnateDB Gene

IDBG-186121 (Sergef)

Protein Structure

UniProt Annotation

Function

Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005087	Ran guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0032316	regulation of Ran GTPase activity
GO:0050709	negative regulation of protein secretion

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1351630

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PFAM

PF00415

PRINTS

PR00633

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80YD6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

27414

UniGene

Mm.76659

RefSeq

NP_038817

MGI ID

MGI Symbol

Sergef

OMIM

CCDS

CCDS21279

HPRD

IMGT

EMBL

AJ243952 AK145819 AK147848 BC049603 BC119533 BC119534

GenPept

AAH49603 AAI19534 AAI19535 BAE26671 BAE28179 CAB60840