InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnaseh2b

Summary

InnateDB Protein

IDBP-171711.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnaseh2b

Protein Name

ribonuclease H2, subunit B

Synonyms

1110019N06Rik; 2610207P08Rik; Dleu8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022499

InnateDB Gene

IDBG-171709 (Rnaseh2b)

Protein Structure

UniProt Annotation

Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269PubMed:19923215}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004523	RNA-DNA hybrid ribonuclease activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006401	RNA catabolic process
GO:0009259	ribonucleotide metabolic process
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0010629	negative regulation of gene expression
GO:0048146	positive regulation of fibroblast proliferation
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000001	regulation of DNA damage checkpoint