Version 5.4
Mus musculus Gene: Rnaseh2b
Summary
InnateDB Gene IDBG-171709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnaseh2b
Gene Name ribonuclease H2, subunit B
Synonyms 1110019N06Rik; 2610207P08Rik; Dleu8
Species Mus musculus
Ensembl Gene ENSMUSG00000021932
Encoded Proteins
IDBP-171711
ribonuclease H2, subunit B
IDBP-620379
ribonuclease H2, subunit B
IDBP-620383
ribonuclease H2, subunit B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136104:
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:62292589-62372992
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022499 ENSMUSP00000022499
ENSMUST00000156608
ENSMUST00000166879 ENSMUSP00000129165
ENSMUST00000169728 ENSMUSP00000132267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006401 RNA catabolic process
GO:0009259 ribonucleotide metabolic process
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010629 negative regulation of gene expression
GO:0048146 positive regulation of fibroblast proliferation
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136104
View Gene Order
ENSBTAG00000020149
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03030
DNA replication pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03030
DNA replication pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PYC5
UniProt Splice Variant
Entrez Gene 67153
UniGene
RefSeq NM_026001
OMIM
CCDS CCDS27189
HPRD
IMGT
MGI ID MGI:1914403
MGI Symbol Rnaseh2b
EMBL AC154805
GenPept
RNA Seq Atlas 67153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca