InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Accn3

Summary

InnateDB Protein

IDBP-141044.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Accn3

Protein Name

amiloride-sensitive cation channel 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039914

InnateDB Gene

IDBG-141042 (Accn3)

Protein Structure

UniProt Annotation

Function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269PubMed:11754838, ECO:0000269PubMed:12060708, ECO:0000269PubMed:14659506}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15051137}; Multi-pass membrane protein {ECO:0000269PubMed:15051137}. Cytoplasm {ECO:0000269PubMed:15051137}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4 (By similarity). In part cytoplasmic in cochlea cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver, lung, kidney, testis, brain, eye and cochlea. Expressed in spiral ganglion and sensory hair cells of the organ of Corti in the cochlea (at protein level). Expressed in dorsal root ganglion innervating muscles and spinal chord. Expressed in peripheral sensory nerve termimals like nerves of the Meissner corpuscle, palisades of lanceolate nerve endings, site of mechanoreception in guard hair follicles, and Merkel cell-neurite complexes. {ECO:0000269PubMed:11754838, ECO:0000269PubMed:14659506, ECO:0000269PubMed:15051137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0030165	PDZ domain binding
GO:0042931	enterobactin transporter activity

Biological Process

GO:0001101	response to acid
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0009408	response to heat
GO:0009612	response to mechanical stimulus
GO:0010447	response to acidity
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042930	enterobactin transport
GO:0050907	detection of chemical stimulus involved in sensory perception
GO:0050915	sensory perception of sour taste
GO:0050961	detection of temperature stimulus involved in sensory perception
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0050974	detection of mechanical stimulus involved in sensory perception