InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Accn3

Summary

InnateDB Gene

IDBG-141042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Accn3

Gene Name

amiloride-sensitive cation channel 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038276

Encoded Proteins

IDBP-141044

amiloride-sensitive cation channel 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213199:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:24413451-24417834

Strand

Forward strand

Band

Transcripts

ENSMUST00000049346

ENSMUSP00000039914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0030165	PDZ domain binding
GO:0042931	enterobactin transporter activity

Biological Process

GO:0001101	response to acid
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0009408	response to heat
GO:0009612	response to mechanical stimulus
GO:0010447	response to acidity
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042930	enterobactin transport
GO:0050907	detection of chemical stimulus involved in sensory perception
GO:0050915	sensory perception of sour taste
GO:0050961	detection of temperature stimulus involved in sensory perception
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0050974	detection of mechanical stimulus involved in sensory perception

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000213199

View Gene Order

ENSBTAG00000007762

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q6X1Y6

TrEMBL

UniProt Splice Variant

Entrez Gene

171209

UniGene

Mm.299636

RefSeq

NM_183000

OMIM

CCDS

CCDS51433

HPRD

IMGT

MGI ID

MGI:2159339

MGI Symbol

Asic3

EMBL

AC113055 AY261387

GenPept

AAP88539

RNA Seq Atlas

171209