InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttyh1

Summary

InnateDB Protein

IDBP-137182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttyh1

Protein Name

tweety homolog 1 (Drosophila)

Synonyms

4930459B04Rik; 6330408P11Rik; tty;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078384

InnateDB Gene

IDBG-137176 (Ttyh1)

Protein Structure

UniProt Annotation

Function

Probable chloride channel. Isoform 3 may be a Ca(2+)- independent and swelling-activated chloride channel, possibly involved in regulation of cell volume. May be involved in cell adhesion (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted mainly to neural tissues. Strongly expressed in brain and eye. {ECO:0000269PubMed:17116230}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0072320	volume-sensitive chloride channel activity

Biological Process

GO:0006821	chloride transport
GO:0007067	mitotic nuclear division
GO:0016337	single organismal cell-cell adhesion
GO:0031589	cell-substrate adhesion
GO:0044070	regulation of anion transport
GO:0046847	filopodium assembly
GO:1902476	chloride transmembrane transport