Version 5.4
Mus musculus Gene: Ttyh1
Summary
InnateDB Gene IDBG-137176.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttyh1
Gene Name tweety homolog 1 (Drosophila)
Synonyms 4930459B04Rik; 6330408P11Rik; tty
Species Mus musculus
Ensembl Gene ENSMUSG00000030428
Encoded Proteins
IDBP-137178
tweety homolog 1 (Drosophila)
IDBP-137182
tweety homolog 1 (Drosophila)
IDBP-401648
tweety homolog 1 (Drosophila)
IDBP-539485
tweety homolog 1 (Drosophila)
IDBP-540361
tweety homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167614:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4119408-4136706
Strand Forward strand
Band A1
Transcripts
ENSMUST00000032594 ENSMUSP00000032594
ENSMUST00000079415 ENSMUSP00000078384
ENSMUST00000119661 ENSMUSP00000113937
ENSMUST00000130150
ENSMUST00000126971
ENSMUST00000129423 ENSMUSP00000120182
ENSMUST00000148760
ENSMUST00000153673 ENSMUSP00000115623
ENSMUST00000151959
ENSMUST00000134536
ENSMUST00000132400
ENSMUST00000148951
ENSMUST00000128317
ENSMUST00000139789
ENSMUST00000140637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005509 calcium ion binding
GO:0072320 volume-sensitive chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0007067 mitotic nuclear division
GO:0016337 single organismal cell-cell adhesion
GO:0031589 cell-substrate adhesion
GO:0044070 regulation of anion transport
GO:0046847 filopodium assembly
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0030868 smooth endoplasmic reticulum membrane
GO:0031527 filopodium membrane
GO:0032433 filopodium tip
GO:0034707 chloride channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167614
View Gene Order
ENSBTAG00000003470
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29729 Mm.407829 Mm.474056
RefSeq NM_001001454 NM_001109765 NM_021324
OMIM
CCDS CCDS20730 CCDS51970
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca