Version 5.4
Homo sapiens Protein: SYT11
Summary
InnateDB Protein IDBP-103320.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT11
Protein Name synaptotagmin XI
Synonyms SYT12; sytXI;
Species Homo sapiens
Ensembl Protein ENSP00000357307
InnateDB Gene IDBG-103318 (SYT11)
Protein Structure
UniProt Annotation
Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:12925569}; Single-pass membrane protein {ECO:0000269PubMed:12925569}. Cell junction, synapse {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
PFAM PF00168
PRINTS PR00360
PR00399
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT88
PhosphoSite PhosphoSite-Q9BT88
TrEMBL B4DK40
UniProt Splice Variant
Entrez Gene 23208
UniGene Hs.627498
RefSeq NP_689493
HUGO HGNC:19239
OMIM 608741
CCDS CCDS1122
HPRD 12289
IMGT
EMBL AK027540 AK074931 AK296378 AL139128 BC004291 BC013690 BC039205 CR749792 D38522
GenPept AAH04291 AAH13690 AAH39205 BAA07527 BAB55186 BAC11300 BAG59052 CAH18653 CAH69948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca