Version 5.4
Homo sapiens Gene: UNC5CL
Summary
InnateDB Gene IDBG-86449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC5CL
Gene Name unc-5 homolog C (C. elegans)-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124602
Encoded Proteins
IDBP-86451
unc-5 homolog C (C. elegans)-like
IDBP-86453
unc-5 homolog C (C. elegans)-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22158417
UNC5CL is a factor in epithelial inflammation where it activates the pro-inflammatory IRAK signalling cascade in a MYD88-independent manner.
InnateDB Annotation from Orthologs
Summary
PMID 22158417
[Mus musculus] Unc5cl is a factor in epithelial inflammation where it activates the pro-inflammatory IRAK signalling cascade in a Myd88-independent manner.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41026911-41039217
Strand Reverse strand
Band p21.1
Transcripts
ENST00000244565 ENSP00000244565
ENST00000373164 ENSP00000362258
ENST00000470102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043592
View Gene Order
ENSBTAG00000002919
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.158357
RefSeq NM_173561
HUGO
OMIM
CCDS CCDS4847
HPRD 09844
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca