Version 5.4
Mus musculus Gene: Unc5cl
Summary
InnateDB Gene IDBG-190027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc5cl
Gene Name unc-5 homolog C (C. elegans)-like
Synonyms 2510009H09Rik; BB155270; Zud
Species Mus musculus
Ensembl Gene ENSMUSG00000043592
Encoded Proteins
IDBP-190029
unc-5 homolog C (C. elegans)-like
IDBP-537915
unc-5 homolog C (C. elegans)-like
IDBP-535557
unc-5 homolog C (C. elegans)-like
IDBP-535788
unc-5 homolog C (C. elegans)-like
IDBP-537574
unc-5 homolog C (C. elegans)-like
IDBP-537916
unc-5 homolog C (C. elegans)-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22158417
Unc5cl is a factor in epithelial inflammation where it activates the pro-inflammatory IRAK signalling cascade in a Myd88-independent manner.
InnateDB Annotation from Orthologs
Summary
PMID 22158417
[Homo sapiens] UNC5CL is a factor in epithelial inflammation where it activates the pro-inflammatory IRAK signalling cascade in a MYD88-independent manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124602:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48454901-48539714
Strand Forward strand
Band C
Transcripts
ENSMUST00000074574 ENSMUSP00000074159
ENSMUST00000161587 ENSMUSP00000124990
ENSMUST00000162313 ENSMUSP00000125101
ENSMUST00000162132 ENSMUSP00000124197
ENSMUST00000161418 ENSMUSP00000125243
ENSMUST00000162467 ENSMUSP00000125598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0008150 biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124602
View Gene Order
ENSBTAG00000002919
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6TRC7
UniProt Splice Variant
Entrez Gene 76589
UniGene Mm.311629
RefSeq NM_152823 XM_006525099 XM_006525102
OMIM
CCDS CCDS28870
HPRD
IMGT
MGI ID MGI:1923839
MGI Symbol Unc5cl
EMBL AC165291
GenPept
RNA Seq Atlas 76589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca