Version 5.4
Homo sapiens Gene: BCL2L12
Summary
InnateDB Gene IDBG-63278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L12
Gene Name BCL2-like 12 (proline rich)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126453
Encoded Proteins
IDBP-63280
BCL2-like 12 (proline rich)
IDBP-63282
BCL2-like 12 (proline rich)
IDBP-383343
BCL2-like 12 (proline rich)
IDBP-765859
IDBP-765870
IDBP-760365
IDBP-766214
IDBP-813721
BCL2-like 12 (proline rich)
IDBP-813724
BCL2-like 12 (proline rich)
IDBP-813725
BCL2-like 12 (proline rich)
IDBP-813727
BCL2-like 12 (proline rich)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49665142-49673916
Strand Forward strand
Band q13.33
Transcripts
ENST00000246785 ENSP00000246785
ENST00000246784 ENSP00000246784
ENST00000441864 ENSP00000393803
ENST00000600947 ENSP00000470644
ENST00000598306 ENSP00000472214
ENST00000598979 ENSP00000471919
ENST00000594157 ENSP00000469216
ENST00000601168
ENST00000594793
ENST00000616144 ENSP00000482218
ENST00000619007 ENSP00000483272
ENST00000614495 ENSP00000482154
ENST00000611631 ENSP00000478415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0005515 protein binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:2000773 negative regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003190
View Gene Order
ENSBTAG00000006638
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001040668 NM_001282516 NM_001282517 NM_001282519 NM_001282520 NM_001282521 NM_138639
HUGO
OMIM
CCDS CCDS12776 CCDS46144 CCDS74423 CCDS74424
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca