Version 5.4
Mus musculus Gene: Bcl2l12
Summary
InnateDB Gene IDBG-181037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl2l12
Gene Name BCL2-like 12 (proline rich)
Synonyms 2810475P17Rik; 5430429M05Rik; Bcl-L12; Bcl2-L12
Species Mus musculus
Ensembl Gene ENSMUSG00000003190
Encoded Proteins
IDBP-181039
BCL2-like 12 (proline rich)
IDBP-540589
BCL2-like 12 (proline rich)
IDBP-533313
BCL2-like 12 (proline rich)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126453:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44991222-44998712
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000003290 ENSMUSP00000003290
ENSMUST00000128816
ENSMUST00000124235
ENSMUST00000149765
ENSMUST00000124232 ENSMUSP00000115794
ENSMUST00000152341 ENSMUSP00000114373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:2000773 negative regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126453
View Gene Order
ENSBTAG00000006638
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.261006
RefSeq NM_029410
OMIM
CCDS CCDS21223
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca