InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC22A8

Summary

InnateDB Gene

IDBG-52313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A8

Gene Name

solute carrier family 22 (organic anion transporter), member 8

Synonyms

OAT3

Species

Homo sapiens

Ensembl Gene

ENSG00000149452

Encoded Proteins

IDBP-52315

solute carrier family 22 (organic anion transporter), member 8

IDBP-52317

solute carrier family 22 (organic anion transporter), member 8

IDBP-376678

solute carrier family 22 (organic anion transporter), member 8

IDBP-585633

solute carrier family 22 (organic anion transporter), member 8

IDBP-583540

solute carrier family 22 (organic anion transporter), member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62989154-63015839

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000336232	ENSP00000337335
ENST00000311438	ENSP00000311463
ENST00000451262
ENST00000430500	ENSP00000398548
ENST00000539841
ENST00000545207	ENSP00000441658
ENST00000535878	ENSP00000443368
ENST00000542795
ENST00000542904
ENST00000544707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005452	inorganic anion exchanger activity
GO:0008514	organic anion transmembrane transporter activity
GO:0015075	ion transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0009636	response to toxic substance
GO:0015697	quaternary ammonium group transport
GO:0031427	response to methotrexate
GO:0034220	ion transmembrane transport
GO:0034635	glutathione transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063796

View Gene Order

ENSBTAG00000013644

Not yet available

Pathways

NETPATH

REACTOME

REACT_22310

Organic anion transport pathway

REACT_19305

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_22345

Organic cation/anion/zwitterion transport pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.266223

RefSeq

NM_001184732 NM_001184733 NM_001184736 NM_004254

HUGO

OMIM

CCDS

CCDS53643 CCDS53644 CCDS8042

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas