InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tollip

Summary

InnateDB Gene

IDBG-212409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tollip

Gene Name

toll interacting protein

Synonyms

4930403G24Rik; 4931428G15Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025139

Encoded Proteins

IDBP-212411

toll interacting protein

IDBP-212413

toll interacting protein

IDBP-534197

toll interacting protein

IDBP-539341

toll interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25586187

Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.

InnateDB Annotation from Orthologs

Summary

PMID 11751856

[Homo sapiens] TOLLIP is a negative regulator of toll-like receptor (TLR) mediated signalling which serves to limit the production of pro-inflammatory mediators during inflammation and infection.

PMID 11751856

[Homo sapiens] TOLLIP over-expression inhibits activation of NF-kappaB in response to IL1, the TLR2 and TLR4 ligands.

PMID 19716405

[Homo sapiens] TOLLIP/IRAK1/TRAF6 complex formation is positively regulated by RCAN1 (DSCR1) short isoform, resulting in the modulation of IL-1R-mediated signalling pathways.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078902:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:141874813-141918507

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055819	ENSMUSP00000051485
ENSMUST00000001950	ENSMUSP00000001950
ENSMUST00000151890	ENSMUSP00000118336
ENSMUST00000130439	ENSMUSP00000117938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005150	interleukin-1, Type I receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0030855	epithelial cell differentiation
GO:0033235	positive regulation of protein sumoylation
GO:0036010	protein localization to endosome
GO:0045087	innate immune response (InnateDB)