InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TOLLIP

Summary

InnateDB Gene

IDBG-19140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOLLIP

Gene Name

toll interacting protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000078902

Encoded Proteins

IDBP-19142

toll interacting protein

IDBP-19144

toll interacting protein

IDBP-590113

toll interacting protein

IDBP-598397

toll interacting protein

IDBP-587303

toll interacting protein

IDBP-594326

toll interacting protein

IDBP-597786

toll interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 11751856

TOLLIP is a negative regulator of toll-like receptor (TLR) mediated signalling which serves to limit the production of pro-inflammatory mediators during inflammation and infection.

PMID 11751856

TOLLIP over-expression inhibits activation of NF-kappaB in response to IL1, the TLR2 and TLR4 ligands.

PMID 19716405

TOLLIP/IRAK1/TRAF6 complex formation is positively regulated by RCAN1 (DSCR1) short isoform, resulting in the modulation of IL-1R-mediated signalling pathways.

InnateDB Annotation from Orthologs

Summary

PMID 25586187

[Mus musculus] Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.

Entrez Gene

Summary

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:1274371-1309654

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000317204	ENSP00000314733
ENST00000263646	ENSP00000263646
ENST00000527886	ENSP00000434035
ENST00000525159	ENSP00000432668
ENST00000530506	ENSP00000436393
ENST00000527938	ENSP00000432778
ENST00000530541	ENSP00000434494
ENST00000528719
ENST00000527746
ENST00000527638
ENST00000532551
ENST00000530821
ENST00000527085

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005150	interleukin-1, Type I receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0016310	phosphorylation
GO:0030855	epithelial cell differentiation
GO:0033235	positive regulation of protein sumoylation
GO:0035556	intracellular signal transduction
GO:0036010	protein localization to endosome
GO:0045087	innate immune response (InnateDB)
GO:0045321	leukocyte activation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0045092	interleukin-18 receptor complex
GO:0045323	interleukin-1 receptor complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome