InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnk1

Summary

InnateDB Gene

IDBG-192267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnk1

Gene Name

tyrosine kinase, non-receptor, 1

Synonyms

Kos1; Tnk1a; Tnk1b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001583

Encoded Proteins

IDBP-192269

tyrosine kinase, non-receptor, 1

IDBP-264129

tyrosine kinase, non-receptor, 1

IDBP-264131

tyrosine kinase, non-receptor, 1

IDBP-540938

tyrosine kinase, non-receptor, 1

IDBP-537451

tyrosine kinase, non-receptor, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24449862

[Homo sapiens] TNK1 is a component of the IFN-JAK-STAT signalling cascade and is a critical antiviral host factor where its abundance is inversely correlated to viral replication and contributes to the hepatocytic response to antiviral treatment.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174292:
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69851005-69858730

Strand

Reverse strand

Band

Transcripts

ENSMUST00000001626	ENSMUSP00000001626
ENSMUST00000108628	ENSMUSP00000104268
ENSMUST00000108626	ENSMUSP00000104266
ENSMUST00000156507	ENSMUSP00000120585
ENSMUST00000125571	ENSMUSP00000118490

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030308	negative regulation of cell growth
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030054	cell junction

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000174292

View Gene Order

ENSBTAG00000017739

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.358793

RefSeq

NM_031880 XM_006534554 XM_006534555

OMIM

CCDS

CCDS24917

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas