InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FPR1

Summary

InnateDB Protein

IDBP-66272.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FPR1

Protein Name

formyl peptide receptor 1

Synonyms

FMLP; FPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000302707

InnateDB Gene

IDBG-66270 (FPR1)

Protein Structure

UniProt Annotation

Function

High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Neutrophils.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004982	N-formyl peptide receptor activity
GO:0005515	protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0045087	innate immune response (InnateDB)