InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FPR1

Summary

InnateDB Gene

IDBG-66270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FPR1

Gene Name

formyl peptide receptor 1

Synonyms

FMLP; FPR

Species

Homo sapiens

Ensembl Gene

ENSG00000171051

Encoded Proteins

IDBP-66272

formyl peptide receptor 1

IDBP-763984

IDBP-766141

IDBP-763398

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25605714

FPR1 and FPR2 are G-protein-coupled receptors that recognize bacterial signal peptides, constituting a novel class of immune activators that contribute to mammalian immune defence against bacteria.

Entrez Gene

Summary

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51745172-51804110

Strand

Reverse strand

Band

q13.41

Transcripts

ENST00000304748	ENSP00000302707
ENST00000600815	ENSP00000472936
ENST00000595042	ENSP00000471493
ENST00000594900	ENSP00000470750

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004982	N-formyl peptide receptor activity
GO:0005515	protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000045551

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_21264

Formyl peptide receptors bind formyl peptides and many other ligands pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa05150

Staphylococcus aureus infection pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001193306 NM_002029

HUGO

OMIM

CCDS

CCDS12839

HPRD

00646

IMGT

EMBL

GenPept

RNA Seq Atlas