InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: METAP2

Summary

InnateDB Protein

IDBP-51684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

METAP2

Protein Name

methionyl aminopeptidase 2

Synonyms

MAP2; MNPEP; p67; p67eIF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000325312

InnateDB Gene

IDBG-51682 (METAP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0016485	protein processing
GO:0018206	peptidyl-methionine modification
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0031365	N-terminal protein amino acid modification
GO:0070084	protein initiator methionine removal

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000994 Peptidase M24, structural domain
IPR001714 Peptidase M24, methionine aminopeptidase
IPR002468 Peptidase M24A, methionine aminopeptidase, subfamily 2

PFAM

PF00557

PRINTS

PR00599

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50579