InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: METAP2

Summary

InnateDB Gene

IDBG-51682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

METAP2

Gene Name

methionyl aminopeptidase 2

Synonyms

MAP2; MNPEP; p67; p67eIF2

Species

Homo sapiens

Ensembl Gene

ENSG00000111142

Encoded Proteins

IDBP-51684

methionyl aminopeptidase 2

IDBP-51686

methionyl aminopeptidase 2

IDBP-589403

methionyl aminopeptidase 2

IDBP-588531

methionyl aminopeptidase 2

IDBP-591550

methionyl aminopeptidase 2

IDBP-602277

methionyl aminopeptidase 2

IDBP-595181

methionyl aminopeptidase 2

IDBP-583658

methionyl aminopeptidase 2

IDBP-587716

methionyl aminopeptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:95473520-95515839

Strand

Forward strand

Band

q22

Transcripts

ENST00000323666	ENSP00000325312
ENST00000261220	ENSP00000261220
ENST00000535095	ENSP00000446052
ENST00000546753	ENSP00000448169
ENST00000549502	ENSP00000448370
ENST00000553151	ENSP00000449004
ENST00000550777	ENSP00000448614
ENST00000551840	ENSP00000450063
ENST00000549136
ENST00000549808	ENSP00000447661
ENST00000546478

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007603	phototransduction, visible light
GO:0008152	metabolic process
GO:0016056	rhodopsin mediated signaling pathway
GO:0016485	protein processing
GO:0018206	peptidyl-methionine modification
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0031365	N-terminal protein amino acid modification
GO:0070084	protein initiator methionine removal

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036112

View Gene Order

ENSBTAG00000019944

Not yet available

Pathways

NETPATH

REACTOME

REACT_111102

Signal Transduction pathway

REACT_160102

Diseases associated with visual transduction pathway

REACT_160125

Visual phototransduction pathway

REACT_163722

The phototransduction cascade pathway

REACT_163919

Inactivation, recovery and regulation of the phototransduction cascade pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.444986 Hs.713984

RefSeq

NM_006838 XM_005268583

HUGO

OMIM

CCDS

CCDS9052

HPRD

03522

IMGT

EMBL

GenPept

RNA Seq Atlas