Version 5.4
Homo sapiens Protein: AP1S3
Summary
InnateDB Protein IDBP-389134.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1S3
Protein Name adaptor-related protein complex 1, sigma 3 subunit
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000388738
InnateDB Gene IDBG-82268 (AP1S3)
Protein Structure
UniProt Annotation
Function Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular Localization Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Disease Associations
Tissue Specificity Widely expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005905 coated pit
GO:0030117 membrane coat
GO:0030659 cytoplasmic vesicle membrane
GO:0032588 trans-Golgi network membrane
Protein Structure and Domains
PDB ID
InterPro IPR011012 Longin-like domain
IPR016635 Adaptor protein complex, sigma subunit
IPR022775 AP complex, mu/sigma subunit
PFAM PF01217
PRINTS
PIRSF PIRSF015588
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PC3
PhosphoSite PhosphoSite-Q96PC3
TrEMBL Q53R44
UniProt Splice Variant
Entrez Gene 130340
UniGene
RefSeq
HUGO HGNC:18971
OMIM 615781
CCDS
HPRD 16495
IMGT
EMBL AC012512 AC093884 AF393369 AK299026 BC009606 BC021898
GenPept AAH09606 AAH21898 AAL09586 AAY24166 BAG61103

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca