Version 5.4
Homo sapiens Gene: AP1S3
Summary
InnateDB Gene IDBG-82268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1S3
Gene Name adaptor-related protein complex 1, sigma 3 subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152056
Encoded Proteins
IDBP-82272
adaptor-related protein complex 1, sigma 3 subunit
IDBP-237052
adaptor-related protein complex 1, sigma 3 subunit
IDBP-237054
adaptor-related protein complex 1, sigma 3 subunit
IDBP-292981
adaptor-related protein complex 1, sigma 3 subunit
IDBP-389132
adaptor-related protein complex 1, sigma 3 subunit
IDBP-389133
adaptor-related protein complex 1, sigma 3 subunit
IDBP-389134
adaptor-related protein complex 1, sigma 3 subunit
IDBP-389135
adaptor-related protein complex 1, sigma 3 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:223751686-223838027
Strand Reverse strand
Band q36.1
Transcripts
ENST00000334271 ENSP00000333888
ENST00000396654 ENSP00000379891
ENST00000396653 ENSP00000379890
ENST00000409375 ENSP00000387199
ENST00000443700 ENSP00000397155
ENST00000415298 ENSP00000401705
ENST00000446015 ENSP00000388738
ENST00000444408 ENSP00000399738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005905 coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030659 cytoplasmic vesicle membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054702
View Gene Order
ENSBTAG00000011133
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E966
UniProt Splice Variant
Entrez Gene 130340
UniGene
RefSeq NM_001039569
HUGO HGNC:18971
OMIM 615781
CCDS CCDS42827
HPRD 16495
IMGT
EMBL AC012512 AC093884 CH471063
GenPept EAW70814
RNA Seq Atlas 130340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca