Version 5.4
Mus musculus Protein: Hnmt
Summary
InnateDB Protein IDBP-141974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnmt
Protein Name histamine N-methyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062747
InnateDB Gene IDBG-141972 (Hnmt)
Protein Structure
UniProt Annotation
Function Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0002347 response to tumor cell
GO:0006972 hyperosmotic response
GO:0007420 brain development
GO:0014075 response to amine
GO:0032259 methylation
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2153181
InterPro IPR016673 Histamine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM
PRINTS
PIRSF PIRSF016616
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VF2
PhosphoSite PhosphoSite-Q91VF2
TrEMBL A2AQK4
UniProt Splice Variant
Entrez Gene 140483
UniGene Mm.406925
RefSeq NP_536710
MGI ID
MGI Symbol Hnmt
OMIM
CCDS CCDS15731
HPRD
IMGT
EMBL AB070523 AB070524 AB444950 AB444951 AF297037 AF297039 AF297040 AF297041 AF297042 AF297043 AF298150 AK050129 AK160131 BC033928 CH466542
GenPept AAH33928 AAL09305 AAL09306 BAB84318 BAB84320 BAC34081 BAE35648 BAG66245 BAG66246 EDL08158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca