Version 5.4
Mus musculus Gene: Hnmt
Summary
InnateDB Gene IDBG-141972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnmt
Gene Name histamine N-methyltransferase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026986
Encoded Proteins
IDBP-141974
histamine N-methyltransferase
IDBP-251638
histamine N-methyltransferase
IDBP-251640
histamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150540:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24002910-24049394
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000051416 ENSMUSP00000062747
ENSMUST00000114498 ENSMUSP00000110142
ENSMUST00000114497 ENSMUSP00000110141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0002347 response to tumor cell
GO:0006972 hyperosmotic response
GO:0007420 brain development
GO:0014075 response to amine
GO:0032259 methylation
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0051384 response to glucocorticoid
GO:0070555 response to interleukin-1
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150540
View Gene Order
ENSBTAG00000014432
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00340
Histidine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00340
Histidine metabolism pathway
INOH
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.33120 Mm.406925
RefSeq NM_080462 XM_006497670 XM_006497671
OMIM
CCDS CCDS15731
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca