Version 5.4
Homo sapiens Gene: SNCB
Summary
InnateDB Gene IDBG-59051.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCB
Gene Name synuclein, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000074317
Encoded Proteins
IDBP-59053
synuclein, beta
IDBP-243107
synuclein, beta
IDBP-482637
synuclein, beta
IDBP-476901
synuclein, beta
IDBP-813093
synuclein, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:176620084-176630556
Strand Reverse strand
Band q35.2
Transcripts
ENST00000310112 ENSP00000308057
ENST00000393693 ENSP00000377296
ENST00000510387 ENSP00000424073
ENST00000506696 ENSP00000422223
ENST00000508006
ENST00000614675 ENSP00000479489
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0007268 synaptic transmission
GO:0042417 dopamine metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0050808 synapse organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0030426 growth cone
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034891
View Gene Order
ENSBTAG00000009803
Not yet available
Cross-References
SwissProt Q16143
TrEMBL A0A024R7R3
UniProt Splice Variant
Entrez Gene 6620
UniGene
RefSeq NM_003085 NM_001001502 XM_006714916
HUGO HGNC:11140
OMIM 602569
CCDS CCDS4406
HPRD 03980
IMGT
EMBL AF053134 AF053135 AF053136 BC002902 BT006627 CH471195 CR457027 S69965
GenPept AAB30860 AAC80286 AAH02902 AAP35273 CAG33308 EAW85063 EAW85064
RNA Seq Atlas 6620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca