Version 5.4
Mus musculus Gene: Sncb
Summary
InnateDB Gene IDBG-154303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sncb
Gene Name synuclein, beta
Synonyms AI838531; betaSYN
Species Mus musculus
Ensembl Gene ENSMUSG00000034891
Encoded Proteins
IDBP-154305
synuclein, beta
IDBP-536205
synuclein, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074317:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:54758860-54766595
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000036825 ENSMUSP00000043074
ENSMUST00000134110 ENSMUSP00000116296
ENSMUST00000153829
ENSMUST00000138067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0007268 synaptic transmission
GO:0042417 dopamine metabolic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0050808 synapse organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0030426 growth cone
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000074317
View Gene Order
ENSBTAG00000009803
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.200843
RefSeq NM_033610 XM_006517015
OMIM
CCDS CCDS36670
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca