InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AK8

Summary

InnateDB Protein

IDBP-90435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK8

Protein Name

adenylate kinase 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298545

InnateDB Gene

IDBG-90433 (AK8)

Protein Structure

UniProt Annotation

Function

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269PubMed:21080915, ECO:0000269PubMed:23416111}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:21080915}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004127	cytidylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0021591	ventricular system development

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02197
PF05191

PRINTS

PR00094

PIRSF

SMART

SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt