InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNF1B

Summary

InnateDB Protein

IDBP-808959.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNF1B

Protein Name

HNF1 homeobox B

Synonyms

FJHN; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000480291

InnateDB Gene

IDBG-774405 (HNF1B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001714	endodermal cell fate specification
GO:0001822	kidney development
GO:0001826	inner cell mass cell differentiation
GO:0001889	liver development
GO:0006366	transcription from RNA polymerase II promoter
GO:0007492	endoderm development
GO:0009749	response to glucose
GO:0009952	anterior/posterior pattern specification
GO:0010628	positive regulation of gene expression
GO:0030073	insulin secretion
GO:0030111	regulation of Wnt signaling pathway
GO:0030902	hindbrain development
GO:0031018	endocrine pancreas development
GO:0035565	regulation of pronephros size
GO:0039020	pronephric nephron tubule development
GO:0042663	regulation of endodermal cell fate specification
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048557	embryonic digestive tract morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048793	pronephros development
GO:0048806	genitalia development
GO:0050673	epithelial cell proliferation
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060429	epithelium development
GO:0060677	ureteric bud elongation
GO:0060993	kidney morphogenesis
GO:0061017	hepatoblast differentiation
GO:0061296	negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
GO:0072095	regulation of branch elongation involved in ureteric bud branching
GO:0072164	mesonephric tubule development
GO:0072176	nephric duct development
GO:0072177	mesonephric duct development
GO:0072179	nephric duct formation
GO:0072181	mesonephric duct formation
GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminal
IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR023219 Hepatocyte nuclear factor 1, dimerisation domain

PFAM

PF00046
PF04812
PF04814
PF13413

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35680