InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCEAL7

Summary

InnateDB Protein

IDBP-80510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEAL7

Protein Name

transcription elongation factor A (SII)-like 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361751

InnateDB Gene

IDBG-80504 (TCEAL7)

Protein Structure

UniProt Annotation

Function

Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. {ECO:0000269PubMed:18806825, ECO:0000269PubMed:19966855, ECO:0000269PubMed:20454512}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18806825}.

Disease Associations

Tissue Specificity

Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors. {ECO:0000269PubMed:18806825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006351	transcription, DNA-templated
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated