Version 5.4
Homo sapiens Protein: TNNC2
Summary
InnateDB Protein IDBP-78221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNC2
Protein Name troponin C type 2 (fast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361636
InnateDB Gene IDBG-78217 (TNNC2)
Protein Structure
UniProt Annotation
Function Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0030049 muscle filament sliding
Cellular Component
GO:0005829 cytosol
GO:0005861 troponin complex
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02585
PhosphoSite PhosphoSite-
TrEMBL C9J7T9
UniProt Splice Variant
Entrez Gene 7125
UniGene
RefSeq NP_003270
HUGO HGNC:11944
OMIM 191039
CCDS CCDS13375
HPRD 08929
IMGT
EMBL AK291323 AL008726 AL050348 BC005323 CH471077 CR541864 CR541884 M22307 M33771 M33772 X07898
GenPept AAA61197 AAA91854 AAH05323 BAF84012 CAA30737 CAG46662 CAG46682 EAW75802 EAW75803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca