InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALOX15B

Summary

InnateDB Protein

IDBP-760699.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX15B

Protein Name

Synonyms

15-LOX-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000460332

InnateDB Gene

IDBG-27642 (ALOX15B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0016165	lipoxygenase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding
GO:0050473	arachidonate 15-lipoxygenase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0030336	negative regulation of cell migration
GO:0030850	prostate gland development
GO:0030856	regulation of epithelial cell differentiation
GO:0044281	small molecule metabolic process
GO:0045786	negative regulation of cell cycle
GO:0045926	negative regulation of growth
GO:0051122	hepoxilin biosynthetic process
GO:0055114	oxidation-reduction process
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019898	extrinsic component of membrane