Version 5.4
Homo sapiens Protein: SPAG4
Summary
InnateDB Protein IDBP-70534.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG4
Protein Name sperm associated antigen 4
Synonyms CT127; SUN4;
Species Homo sapiens
Ensembl Protein ENSP00000363391
InnateDB Gene IDBG-70532 (SPAG4)
Protein Structure
UniProt Annotation
Function May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250}. Note=In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0007283 spermatogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008979 Galactose-binding domain-like
IPR012919 Sad1/UNC-like, C-terminal
PFAM PF07738
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPE6
PhosphoSite PhosphoSite-Q9NPE6
TrEMBL C9JJZ6
UniProt Splice Variant
Entrez Gene 6676
UniGene Hs.123159
RefSeq NP_003107
HUGO HGNC:11214
OMIM 603038
CCDS CCDS13259
HPRD 04330
IMGT
EMBL AF043344 AF262992 AF262993 AL109827
GenPept AAC32052 AAF75267 AAF75268 CAB87609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca