Bos taurus Protein: MICAL3
Summary
InnateDB Protein IDBP-693730.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MICAL3
Protein Name Uncharacterized protein
Synonyms MICAL-3;
Species Bos taurus
Ensembl Protein ENSBTAP00000053971
InnateDB Gene IDBG-641327 (MICAL3)
Protein Structure
UniProt Annotation
Function Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Mainly localizes in the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004497 monooxygenase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0046872 metal ion binding
GO:0071949 FAD binding
Biological Process
GO:0006887 exocytosis
GO:0007010 cytoskeleton organization
GO:0008152 metabolic process
GO:0030042 actin filament depolymerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR001781 Zinc finger, LIM-type
IPR002938 Monooxygenase, FAD-binding
IPR003042 Aromatic-ring hydroxylase-like
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
IPR022735 Domain of unknown function DUF3585
PFAM PF00307
PF00412
PF01494
PF11971
PF12130
PRINTS PR00420
PIRSF
SMART SM00033
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt G3MWR8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532244
UniGene Bt.105026
RefSeq XP_002687965
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014628 DAAA02014629
GenPept