InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TTYH1

Summary

InnateDB Protein

IDBP-68633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTYH1

Protein Name

tweety homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365713

InnateDB Gene

IDBG-68627 (TTYH1)

Protein Structure

UniProt Annotation

Function

Probable chloride channel. May be involved in cell adhesion (By similarity). {ECO:0000250}.Isoform 3 may be a Ca(2+)-independent and swelling- activated chloride channel, possibly involved in regulation of cell volume.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung. {ECO:0000269PubMed:17116230}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005381	iron ion transmembrane transporter activity
GO:0072320	volume-sensitive chloride channel activity

Biological Process

GO:0006821	chloride transport
GO:0006826	iron ion transport
GO:0034220	ion transmembrane transport
GO:0034755	iron ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport